It is understood that enamel development defects (DDE) are a group of alterations that are observed clinically and that occur during biomineralization, that is, during the formation of dental enamel. It has been shown that these types of alterations have a great impact on the aesthetic appearance of patients, therefore, many of them usually present discomfort when smiling and interacting in public, thus generating social isolation that can have a negative impact on the physical and mental well-being of the people who are affected, especially if they are in early childhood and childhood. For dentists, the therapeutic management of these DDE has become a challenge, that is why the present investigation arises from the lack of experimental studies that deal with three techniques used for the treatment of DDE (Microabrasion, Teeth Whitening, Combined Technique), so that the results obtained serve as a reference point for any oral health professional or student of the same, whose intention is the correct choice of a treatment plan for these defects. The main objective of this research was to study and determine what type of treatment is the most effective for the treatment of demarcated opacities-type enamel development defects. A sample of 18 patients attending the dental clinic of the University Cooperativa de Colombia Campus Villavicencio was selected, of which six were proposed to be treated with the microabrasion technique, six with teeth whitening and six with the combined technique, which includes microabrasion and teeth whitening. To identify the best result, a color sample was taken with the guidance of the Vita System 3D Master, degree of mineralization by means of the Diagnodent before and after treatment, and degree of sensitivity by means of the visual analog scale. This study was carried out under the supervision of specialists.