In recent decades, wellness research has gained relevance for its impact on personal development and empowerment. This structure is relevant to the concept of happiness because psychology considers that happy individuals tend to perform better socially, have higher aspirations and total control over their environment. Therefore, it is necessary to know what makes some people happier than others, which is why this study called "Relationship between subjective well-being, self-esteem and school participation in adolescents in the city of Santa Marta" is characterized by the independent measurement and through psychometric tests, of the level of the variables in question. For the purposes of this research, the Scale of Positive Affects and Negative Affects (PANAS) was applied to measure the variable Subjective Well-being, the Self-Esteem Scale corresponding to the Questionnaire for the Evaluation of Problems in Adolescents (Q-PAD) and the School Participation Scale (EPE) to 336 adolescents from educational institutions in the city of Santa Marta, Colombia; so that it is possible to analyze their incidence and interrelation in the population of adolescents, and thus obtain significant information that allows the promotion of well-being, self-esteem and school participation and guarantee of rights of this population in applied contexts such as school.