This investigation was focused on the search and identification of the factors that influence the quality of life of patients with acquired brain injury (ABI). Patients who are undergoing some neuropsychological rehabilitation treatment, with the aim of addressing its effectiveness, analyzing variables and classify perspectives (models, proposals) of intervention, described in scientific studies. It was developed a systematic review tthat involved the search, collection, extraction and organization of different data from some databases. It was based a research question, and we was followed PRISMA guidelines to metodology. In the search phase, 115 articles were manually pre-selected, which then went through filtering processes to yield a total of 30 final articles present in this review. It was concluded that research with a holistic approach, multidisciplinary and comprehensive interventions, favor the quality of life in patients with ABI, and the nuuroplasticitu to the recovery of previous cognitive functions, lost after ABI, according to the different scientific articles analyzed. In addition, it was shown that there is not enough research on this topic in Latin America, and that most research comes from Europe and North America.