Leishmaniasis is a zoonotic disease caused by the protozoan Leishmania spp, which has two stages in its life cycle (amastigote and promastigote). In the amastigote stage, the parasite is forced to live inside the cell. This pathogen mainly attacks of the cells of the immune system, triggering various processes such as an inflammatory response. Currently, in canines, there are different drugs used for its treatment, but these can worsen the condition due to their adverse side effects. Additionally, they are expensive, and their prolonged use tends to develop resistance, which worsens the damage caused by the parasite. For this reason, this article offers alternatives as adjuvants for the treatment and control of this disease that act on the immune system directly or indirectly. For example, domperidone, nucleotides, Active Hexose Correlated Compound (AHCCs), plant extracts, Toll-like receptors (TLRs), and cytokines. Finally, there are commercially available vaccines for use as a preventive method.