During these recent years, a consensus has been reached in various instances on the need to promote entrepreneurship in Colombia as a strategy to generate more jobs and promote economic development. Taking this into account, a relevant place has been taken for the strategies achieving momentum and taking entrepreneurial initiatives that are consolidated in the regional ecosystems. This commitment from different parts of the country has paid off. Through the creation of new productive units. According to the Single Business and Social Registry of the country's Chambers of Commerce. Reports on positive trends are being presented. This document reflects all the learning acquired through the experience obtained in my professional practices within the Empréndelo program and the Santa Marta Chamber of Commerce for Magdalena. Where the structure of what these alliances are looking for is reflected, highlighting that their main objective is to put an end to business informality and thus be able to build an economy that seeks the sustainability of companies in the market and growth that is feasible. And viable for the country and the Department. It is expected that all the information that is raised in this work, contributes to the strengthening of the different methodologies and programs that are advanced from the National Government and the regions to promote entrepreneurship and its formalization, but, that it contributes to the survival of nascent businesses from formation.