Canine distemper virus (CDV) is a viral disease caused by a common morbillivirus in domestic species, canines at an early age. CDV in wild animals has been observed in canids, procyonids, mustelids, big cats, etc. This disease has been reported in Argentina, Chile, and Brazil. In Colombia, it has been reported in three municipalities: Pereira, Caldas, and Tolima in foxes with clinical symptoms like those registered in domestic canines. This concern has arisen during professional, business, and solidarity practice; developed in the Center for Care and Assessment of Wild Fauna located in Barbosa, Antioquia, Valle de Aburrá (CAV-AMVA), at the time of caring for the fox specimens that entered the facilities with advanced neurological signs, confirmed by PCR tests, being the casuistry of great concern, representing a threat to the fauna of the municipalities of the metropolitan area and the facilities. From 2021 to June 2022, twenty-nine individuals were sampled, and ten of them were positive for the presence of CDV, that is, the apparent incidence of this disease in the CAV is 34.5%, which means that 3 out of 10 individuals that enter the facilities have been found positive for distemper, which is why prevention, control, policies and environmental education on the proper ownership of pets must be established, reinforcing vaccination plans for feral individuals (dogs - cats) by municipalities to mitigate this impact on the region's wildlife.