Introduction: dental fluorosis is a condition that appears as the result of excessive intake of Fluoride; found in food, water and oral hygiene accessories during the period of tooth enamel development from the twentieth week, where it can partially or totally affect the tooth enamel, thus causing white, yellow, dark brown and in some cases roughness, causing fragility that can generate progressive fractures and an obvious loss of the dental structure. Objective: To evaluate the prevalence of caries, dental fluorosis and associated factors in schoolchildren aged 2 to 5 years in the municipality of Restrepo - Meta. Materials and methods: Analytical cross-sectional study, to estimate the proportion or prevalence, with a confidence of 95%, an error of 5%. Using the thylstrup & fejerskov index, the teeth of children aged 2 to 5 years were evaluated with their applications necessary for the clinical examination and data collection and analysis were subsequently carried out in the SPSS. The inclusion criteria were: Boys and girls from 3 to 5 years of school who were born in the municipality of Restrepo-Meta or with time of residence there since the first year of life. The non-acceptance of parents for their child to participate in the study, schoolchildren with orthodontic appliances that impede the assessment of fluorosis, and schoolchildren with cognitive difficulties that impede following basic instructions were excluded. Results: At the clinical examination, 70% had fluorosis and 82.4% had dental caries,71.9% of the surveyed schoolchildren were found in an urban residence area, 63.2% were born in Villavicencio-Meta. The sex that predominated was female with 50.9%, the recoded age of children with the highest prevalence was 4 to 5 years with 59.6%, 75.4% have lived since birth in Restrepo-Meta. Conclusion: The general dentist must be trained to diagnose the condition of dental fluorosis and also strengthen promotion and prevention programs to reduce its incidence.