Introduction: Biotechnologies used in the preservation and viability of the spermatozoon present variation in the resistance of sperm cells, caused by the species, lipid and protein composition of the seminal plasma, in goats there are enzymes that interact negatively with cryoprotectants of animal origin, promoting toxic effects in the sperm. Recent research reports harmful effects of cryopreservation processes, promoting the development and incorporation of antioxidants, proteins and cryoprotective elements that maximize cell resistance. The use of cryoprotective substances, which improve cell resistance and interaction with this enzyme, and avoid the extraction of seminal plasma, has been evaluated, seeking to improve post-thawing sperm viability. Goal: Analyze the use of cryoprotectants that allow optimizing the handling of seminal plasma in caprine cryopreservation. Methodology: Search through the use of keywords and Boolean operators, identifying articles in scientific databases with the help of the PRISMA methodology. Results: Authors concluded that the glycerol (7%) and ethylene glycol (5%) permeant cryoprotectants generate superior protection in the integrity of the membrane than other internal cryoprotectants; egg yolk and soy lecithin-based extenders report similar protection between them when seminal plasma is extracted; Other cryoprotectants such as honey and phytochemicals have proven to be effective on post-thawing motility and viability rates, show potential as a supplement to the extender, with the ability to protect the sperm membrane from oxidative and acrosomal stress damage, and DNA integrity. could prevent the formation of ice crystals during cryopreservation, however, they lack a number of significant studies, which allow a comparison of their advantages in cell preservation. Conclusion: This analysis could help as a guide for the development of more appropriate cryoprotectants in their mode of action, capacity and efficacy in the preservation of goat semen.