A systematic literature analysis was carried out, considering scientific articles related to the subject matter used, with support in the literature review regarding the brief description of the anatomy of the mare, description of the pathogen, presentation of the disease, pathophysiology, clinical signs, diagnostic tools, preventive and control treatments. Metritis in mares is a challenge for the veterinary professional where the decision making in front of the pathology plays a fundamental role to end the infection or later the advance of the infection with very serious consequences for the mare. The clinical considerations in the face of metritis in mares can be of vital importance, since the management of the infection will present us with two paths to follow as is the solution to the metritis or the second path will be the presentation of a secondary syndrome that leads to an endotoxemia concluding in a laminitic picture. In the following literature review we are based on the clinical events before presenting a picture of laminitis following a metritis infection, which is known as metritis syndrome, endotoxemia, laminitis.