Introduction: Canine Distemper is the most common fatal disease worldwide, mainly affecting members of the Canidae, Felidae, Procyonidae and Mustelidae families, it is characterized by being highly contagious with an acute, subacute or chronic course and by presenting high mortality especially in young dogs, since it involves multiple organs such as lymphoid tissues, skin, brain, gastrointestinal and respiratory tracts, which makes its form of presentation very varied, showing clinical manifestations of various kinds in each case. Objective: To develop guide protocols for the appropriate management and treatment of patients with Canine Distemper at the Critical Care Veterinary Clinic. Methodology: To carry out the protocols, the following procedures were taken into account in patients admitted to the Critical Care Veterinary Clinic: reception of the suspicious or positive patient for Canine Distemper, clinical examination, symptomatology: phases and their classification, clinical diagnosis , hospitalization of the patient with CD disease, therapeutic management of the patient with CD, pharmacological management of the patient with CD, patient evolution and patient discharge. Results: Two clear and sequential management protocols were developed for patients with DC, one for puppy patients and another for adult patients; looking for patients to overcome the disease and minimize their mortality rate. Conclusions: With the present work and the Social, Business and Solidarity Practice carried out, it is possible to conclude that the protocol provided to the Critical Care Veterinary Clinic works as an effective strategy that guides veterinarians on how sequential management and specific treatment should be. of patients with Canine Distemper, taking into account the variability of the symptoms that may occur, its importance is highlighted because the literature reports limited and non-specific information on the treatment of the disease. In the same way, this work is a fundamental tool since it provides important information about the disease in clinical practice, which facilitates its diagnosis and prevents it from being mistakenly attributed to other diseases.