Gumboro disease is a highly contagious viral infection that mainly affects young birds. The disease is caused by the Gumboro disease virus, which weakens the birds' immune system and makes them vulnerable to other diseases, which can have serious economic consequences for the poultry industry. To address the prevention of this disease, a systematic review of the scientific literature was conducted using the PRISMA methodology and databases such as Pubmed, Websciencia, Scielo, and Google Scholar. The results highlighted risk factors such as the bird's health status, age of 3 to 6 weeks, immature immune system, and other pathogenic agents. The importance of diagnosis and biosafety was also addressed. Regarding prevention methods, active surveillance, vaccination programs, biosafety, and research were found to be effective tools for controlling the spread of the disease. Vaccination is especially important to protect young birds and prevent the spread of the virus through carrier birds. In conclusion, Gumboro disease represents a significant threat to the poultry industry. Effective preventive measures, including vaccination and biosafety, are necessary to reduce the incidence of the disease and minimize its effects on poultry production. Active surveillance and research are also key tools for the control and prevention of the disease.