High Oleic Palm Oil (HOPO) is a special variety of palm oil characterized by its high content of oleic acid and richness in Vitamin E and carotenoids, precursors of Vitamin A. These phytonutrients are known for their health benefits. This study focused on optimizing the encapsulation process of High Oleic Palm Oil (HOPO) using Refractance Window (RW) drying technology. The primary objective was to determine the optimal conditions for preserving the physical properties, bioactivity, and concentration of phytonutrients in HOPO, while ensuring their bioaccessibility. The study established that the refractance window drying technology is suitable for obtaining HOPO flakes that can be used as a food ingredient. The use of vacuum pressure in the refractive window drying operation was studied as a novelty.