Introduction: Medical education, over time, has become transformed regarding the advances that have occurred in society, science and technology. Also, in recent years, efforts have been made to digitize part of the content generated in this area. However, the COVID-19 pandemic brought about a rapid and challenging change. Objective: To identify the challenges and new approaches regarding the functions of professors of basic medical sciences in pandemic times and their projection towards a hybrid modality. Development: The professors of basic medical sciences are the students’ initial contact with the university reality. They have the function not only of teaching the principles of scientific foundation for clinical practice, but also of motivating students towards being upright professionals. The pandemic has posed multiple challenges, among which the need to promote teacher training stands out, aimed at dealing with unexpected situations. This would allow teaching how to face situations assertively, innovate and give continuity to the transformations carried out. Conclusions: Upon accepting the challenge of modifying the focus of educational practices in basic medical sciences during a pandemic situation, professors should define guidelines towards a hybrid teaching modality, as well as take advantage of these spaces to promote research in the classroom, as well as document the changes made and their impact.