Introduction: The region of the Americas is considered as the most unequal in the world. Human resources in health are essential for overcoming these differences, by means of addressing social determinants. Objective: To review the processes of teaching and learning about social determinants in health science programs in the region of the Americas. Methods: A literature review was carried out by searching for official documents and articles in the databases ofWeb of Science, Clinicalkey, PubMed, Science Direct and Lilacs databases. Sixty-eight documents were selected for the analysis. Results: The region of the Americas has made significant progress in terms of including public policies influencing on determinants and helping human resources in health to be trained under a primary care approach. However, it is important thathealth sciences schools in the region deepen their knowledge of pedagogical and research strategies, as well as they facilitate teaching and learning of the determinants. At the same time, progress has been observed regarding the inclusion of interprofessional education in the region. Conclusions: Health sciences programs should deepen the application of pedagogical and research strategies that facilitate teaching and learning of the determinants, which foster reflection about the role of professionals in reducing social inequalities and improving population health.