The degree of conservation of the cerro páramo de Miraflores natural park (PNCPM) located in southern Colombia between the departments of Huila and Caquetá from 2800 to 3400 masl was studied; area historically affected by problems of public order that in recent years have been reduced due to peace processes, which allowed this pioneering research for the area. For this, the diversity of terrestrial and flying mammals was determined in two sampling units located on the high-Andean and sub-paramo range for 18 days, using Sherman traps, fog nets and trap cameras in February 2017. reports the presence of 19 species belonging to 7 orders, 9 families and 14 genera, the most abundant species being Thomasomys dispar, Thomasomys baeops and Sturnira erythromos; species such as Marmosops fuscatus, Neomicroxus bogotensis, Histiotus montanus and Thomasomys prínceps were recorded only once. The high-Andean strip presented greater wealth and abundance with 16 species and 59 individuals. In addition, species turnover was significant between the two zones (0.8 according to Whittaker and 15% similarity according to Jaccard). These values ​​indicate that the PNCPM is a region of biological importance given the presence of species belonging to several trophic guilds (Insectivores, frugivores, nectarivores and carnivores), which are considered as bioindicators of the good state of conservation in an ecosystem and the integrity of the same, offering different habitats in plant cover associated with the maintenance of populations of these mammals and their prey, such as puma concolor, Tremarctos ornatus and Leopardus pardalis. Additionally, according to the IUCN categorization, 2 vulnerable species are reported, such as T. ornatus and L. tigrinus and 2 with deficient data such as marmosops fuscatus and Thomasomys princeps, which establishes the importance of developing strategies to protect and preserve the PNCPM before the accelerated transformation that occurs in these ecosystems.