Science, technology, and innovation are crucial in addressing the most pressing contemporary issues. However, Colombia lags behind in the development of E-Government, a key variable in strengthening the relationship between society and the state. To close this gap, a model for creating public policy agendas was developed using Twitter, artificial intelligence algorithms, and Big Data collection techniques. In the metropolitan region of Bogotá in 2022, real-time tweets were collected to identify key themes and create a public policy agenda that reflected the population's needs. Data analysis tools were applied, and a bipartite graph was used to visualize the relationships between the selected themes. The final proposed agenda represents an important tool for promoting citizen participation in decision-making and advancing the construction of a fairer and more equitable society. It is noteworthy that the proposed model was able to capture 40,000 tweets published in real-time in the metropolitan region of Bogotá at low cost and high flexibility, demonstrating its effectiveness in analyzing large volumes of data.