The design of an VLE for the teaching of molecular genetics in tenth grade students of the Colegio Virtual Siglo XXI in the city of Bogotá is presented. The work arises from the need to generate an educational resource that promotes improving students' understanding of the subject and the empowerment of scientific skills. The VLE designed has as a pedagogical reference teaching for understanding (TfU) and the flipped classroom methodology and is designed using the ADDIE strategy on the Moodle platform, using the application's own resources and interactive resources available in the cloud. The VLE was evaluated by experts in the pedagogical, technical and communicative component, the evaluation obtained allows the projection of improvements in each of the components to finally conclude the application of the VLE is pertinent, in addition to establishing its suitability in training processes developed under the approach TfU.