At present, the footwear manufacturing sector employs adhesives as part of its inputs, which pose harmful health effects such as neurasthenia, chronic toxic encephalopathy, and ototoxic hypoacusis. In this context, the need arises to seek alternatives that substitute the use of these adhesives in footwear manufacturing processes with inputs that do not pose health risks, possess similar technical and operational characteristics, and do not negatively impact the final product's quality and price.To achieve this, a study of substitute inputs available in the market is conducted. The technical characteristics of these alternatives are evaluated against commonly used adhesives based on criteria such as bonding strength, resistance or flexibility of the bond, open time, ease of application, and odor. Based on this evaluation, the possible alternatives are assessed, and those with the best performance, particularly water-based polychloroprene adhesives, are selected. Using the Quality Function Deployment (QFD) matrix, the most relevant aspect for the substitute adhesive is identified, focusing the product development accordingly. A product and organizational system is proposed to meet the expected growth in demand for footwear adhesives in Bogotá over the next five years. As a result, it is concluded that it is possible to manufacture an adhesive that serves as an alternative to traditionally employed adhesives in footwear manufacturing, which has no harmful effects on health and does not negatively impact the final product's quality and price.