The percutaneous approach to the bile duct in Colombia performs highly for both diagnostic and therapeutic purposes since it allows optimizing and reducing the complications of benign and malignant pathology of the bile duct. Like any minimally invasive procedure, complications can occur. A descriptive patient cohort study was carried out that included 564 patients over a period of 5 years (2015-2020) who had undergone a percutaneous bile duct procedure at the Fundación Cardioinfantil-La Cardio, Colombia. The necessary data were obtained from the clinical history with selection of quantitative and qualitative variables. It was found that the majority of patients were women (66.8%), with an average age of 39.9 years, and the most common procedures were biliary diversion (37.6%) and biliary dilation (23.4%). 13.2% presented complications, the most frequent being inadvertent removal of the biliary diversion catheter or cholecystectomy (4.8%) and complications associated with catheter placement (3.4%). Less common were fistulas, major hemorrhages, transgressions of abdominal structures, and death (between 0.4% and 3%). When comparing complication rates with international standards, it was observed that those related to the procedure technique met quality standards. However, accidental catheter removal had a higher incidence than expected, suggesting the need to review postoperative care protocols and catheter care during the hospital stay to improve patient safety.