This paper analyzes the advisability and constitutionality of the implementation of life imprisonment through the modification of the constitutional prohibition, based on the study of economic, social and legal factors that support the unfeasibility of introducing life imprisonment in Colombia. The text is developed from a theoretical and historical contextualization of penalties in general, and life imprisonment in particular, to its application in comparative law. Subsequently, an analysis is made of the criminal dogmas and social conditions that limit the introduction of life imprisonment in Colombia, while certain potential risks of an economic, political and social nature are formulated, which could occur in case of allowing the penalty in question, from all of which the inconvenience of life imprisonment is derived. Finally, a review is made of national and international norms, firstly, the constitutional provisions, the structure of the State, the notion of the individual and the idea of human dignity; and secondly, the provisions of international treaties. Concluding the incompatibility of the normative article with the penalty of life imprisonment, as well as the constitutional substitution of one of the axial axes of the Political Charter, resulting in the unconstitutionality of the measure.