Introduction: Cystic fibrosis (CF), caused by mutations in the CFTR gene, affects 1 in 2,500-3,500 people worldwide. Multidisciplinary treatments have improved life expectancy, but the increased multiorgan morbidity, especially endocrinological manifestations (EM) such as CF-related diabetes, growth retardation, and low bone density, affects the quality of life. In Colombia, it is necessary to better characterize CF patients to optimize their care. Objective: To characterize the sociodemographic, clinical-endocrinological, and psychological profiles of CF patients in Colombia. Methods: A case series study was conducted with patients treated at the CF center of LaCardio in Bogotá between 2015-2022. Data from medical records were analyzed, focusing on sociodemographic, anthropometric, and clinical variables, particularly EM. Results: A total of 28 patients (50% female) were included, with a median age at diagnosis of 24 months. The F508 mutation was present in 25% of cases. About 89.3% lived in urban areas and 67.8% were from low socioeconomic strata. At the initial consultation, 57.1% presented at least one EM, with the most common being hypovitaminosis D (53%), short stature (39.3%), and dyslipidemia (35.7%). By the end of follow-up, 82.1% had at least one EM. Discussion: This study shows a high prevalence of EM in Colombian pediatric CF patients, exceeding global averages. Further studies are needed to better understand the genetic, endocrinological, and psychological aspects in this population.