The purpose of this research work is to study the relationship between envelope and architectural program and how it influences the configuration of dynamic spaces for the design of an entrepreneurship center, applying four criteria to the two selected variables: comfort, dynamics, productivity and spatial permeability. Based on this, I established that the dynamic spatial configuration tends towards the programmatic implementation of flexible and open spaces, user-space interaction, diverse environments, mixed uses, levels of privacy and own circulations for the promotion of collaborative work; in contrast to the envelope that must respond to reactive or passive interactions of the immediate environment and in turn to the bioclimatic conditions, thus incorporating the qualities of barrier, filter and sensor function. Finally, I took Enrique Leff's Neguentropy theory with the aim of associating the concepts of fractal, fold and rhizome with the program and the envelope allowing to understand from the application of different programmatic strategies that the spatial dynamics tends to constantly transform to find the balance of the variables that influence a dynamic system, while the envelope from the diagrid structure and simplified reciprocal frames conditions the reactive program through hybrid mechanisms that respond to passive cooling and passive heating techniques that take advantage of solar radiation.