This research studies the biopolitics, the corporalities and sexualities arranged in the Colombian State's programs that regulates HIV and adolescent pregnancy between 2003 and 2018. It based on documents produced by the Ministry of Health that design the interventions on the Colombian population. This study arises from my unease at the mutations of biopower and the desire to problematize policies that proclaim themselves ethically and politically neutral. I explore how they turn their interest to the impulse of bodies with low vulnerability to contagion and that self-regulates their sexuality and reproduction. Hence, I trace the connections between knowledge and power to understand the reasons why HIV and teenage pregnancy cause uneasiness for these bioregulatory strategies. On the one hand, I argue that HIV would bring strong macropolitical risks for state security devices and, in addition, it would confront the subject with the micro-political dangers of their own sexuality; on the other, that adolescent pregnancy would be a strong obstacle to the manufacture of subjects who domesticates their future and who makes themselves capitalizable, that is, it is an impediment in the construction of life projects. I conclude the investigation by talking to the current SARS-CoV-2 epidemic. I trace continuities between the management of the two viruses and, at the end, I dare to link the bioregulation of risks with the contemporary mode of production.