The counter-movement jump (CMJ, Counter Movement Jump), is a valuable tool for the control of fatigue and recovery during sports performance sports training. Changes have been evidenced in some phases of the CMJ up to 5 days post effort. On the other hand, intense exercise induces mechanical stress that results in rupture of the sarcolemma allowing the release of enzymes such as creatinkinase (CK) and lactate dehydrogenase (LDH) to the serum. CK and specifically its muscle isoenzyme (CK-MM) has been used as a marker of muscle damage. While LDH in a reversible reaction, catalyzes the oxidation of L-lactate in pyruvate with nicotinamide adenine dinucleotide (NAD +) as a hydrogen acceptor. PURPOSE: To determine how CK and LDH correlate with the counter-movement jump after applying a fatigue test. METHODS: 14 skaters were studied, of which 8 (57.1%) were women, (Age 18 ± 1.93 years, Weight 55.83 ± 4.52 Kg., Size 162 ± 4.84 Cm., BMI 21, 04 ± 1.45). Men (Age 18.16 ± 0.89 years, Weight 61.92 ± 4.13 Kg., Height 175.16 ± 7.60 Cm., BMI 20.19 ± 1.04). All were subjected to a fatigue test, through an outdoor protocol. The counter-movement jump was measured by jumping platforms, while CK and LDH were determined by blood sampling, all these variables were measured pre and at 3 time points [immediate (POST), 24 and 48 hours] fatigue test. RESULTS: The fatigue test produced an increase in the CK levels in both the POST and 24 h with respect to the baseline, but with greater magnitude in the first one (CK: women = 33.7% and 19.6% (p <0.05) and in men = 42.9% and 29.0% (p <0.05) respectively, while for LDH the behavior was similar only during the POST (women = 13.1% and men = 11.0%), while that at 24h and showed a decrease that exceeded the base levels (women = -10.4% and men = -9.4%). The CMJ variables, except for the contraction time, showed a statistically significant decrease at 24 hours. The effects of the fatigue test were established by the effect sizes (ES) in each of the variables analyzed. Biochemicals showed a moderate to large size in men, while women only showed a small effect of CK, at the 24h and 48h point. Regarding the variables of the CMJ, the largest effects were found at the 24h time point, where most of the variables showed the most marked change. CONCLUSION: The high correlation and ES between the levels of CK and LDH with some variables of the CMJ found in the present study, may suggest that changes of these two enzymes occur early after a fatiguing effort, probably as a consequence of some degree of damage of the muscular tissue, result of a level of micro trauma during the high speeds of contraction-relaxation of the tissue during a process of acute fatigue.