Tumaco, a coastal city in Colombia, faces significant risks from earthquakes and tsunamis due to its geographical location and geological characteristics. This master's thesis aims to understand and quantify the complex interaction of these natural hazards, their potential impacts on the city's infrastructure and population, and the implications for disaster resilience. The structural risk assessment begins with an analysis of seismic hazards, which includes the characterization of three earthquake and tsunami scenarios: those that occurred in 1906 and 1979, and a worst-case scenario. This study also incorporates an exposure model that identifies and classifies the city's constructions, considering the structural typologies present, the occupancy classes, and the spatial distribution of these elements. Building upon previous research on seismic and tsunami events in Tumaco, this work adopts a multi-hazard approach to structural risk assessment. By evaluating the complex interaction between these two natural phenomena, the threats are combined using basic probability theory, Boolean logic rules, and assuming the statistical independence of the two phenomena. This approach allows for the development of multi-hazard fragility functions for each level of damage (light, moderate, severe, and collapse) according to the evaluated event, expressed in terms of the probability of damage exceedance based on the PGA value and wave height. Using probabilistic approaches and considering Tumaco's unique characteristics, combined vulnerability surfaces are generated, providing information on the expected damages for each evaluated event, offering a view of the potential magnitude of the impacts on the city. Replacement costs for exposed structures are calculated, and economic loss estimates are derived, highlighting the socioeconomic implications of multi-hazard events in Tumaco. These results are presented in a catalog of maps that allow for a spatial visualization of the structural risk distribution, facilitating the identification of areas with greater vulnerability. Overall, this thesis provides valuable insights into the structural risk posed by multi-hazard events of earthquakes and tsunamis in Tumaco, supporting better decision-making and resilience-building efforts in the region.