Objective: To carry out the epidemiological and clinical description of patients with pemphigus attended at the University Hospital De La Samaritana in the city of Bogota during the years 2016 to 2020. Patients and methods: Observational study, descriptive type series of cases. Includes 21 patients with confirmed diagnosis of pemphigus seen at the Hospital Universitario De La Samaritana during the years 2016 to 2020. Results: The male sex was the most frequent with 52.3%. The mean age was 55 years (SD 17.9 years). The median time of evolution of pemphigus was 7 months (IQR 8.2 months), with an average evolution of the lesions of 12.83 months prior to diagnosis. The most frequent type of pemphigus was vulgar with 47.6%. The anatomical region most compromised by pemphigus was the head with 90.47% and mucosal involvement was present in 71.42% of the cases. In the 21 patients a skin biopsy was performed, being consistent with the diagnosis of pemphigus in 95.23%. The most common biopsy findings were acantholysis in 71.42%, followed by a tumbstones image in 47.61%. Direct immunofluorescence was performed in 20 patients, which corresponds to 95.23% of the sample, being in 17 patients (80.95%) compatible with the diagnosis of pemphigus. 20 patients received topical treatment, 71.42% used an emollient, a corticosteroid in 61.90% and an antibiotic in 9.52%. 21 patients received systemic treatment, in 100% of the cases in which systemic corticosteroid and Azathioprine were used, followed by Rituximab with 42.85% and IV immunoglobulin with 23.8%. Remission was recorded in 42.85% and relapse in 57.14%. There was a mortality of 9.52%