HIV is a deadly disease with important physical, psychological and social health consequences for people who suffer from it, so it ends up being necessary for them to receive social support and have coping strategies to cope with it. This quantitative correlational study aimed to analyze the relationship between perceived social support and coping in adults living with HIV in the Colombian Caribbean region, in a sample of 77 people to whom the Support Questionnaire was applied. Social (MOS) and Modified Coping Strategies Scale (EEC-M.), Including a sociodemographic questionnaire and an additional measure of mental health. The results show a positive and significant correlation between the total score of social support and the coping strategies, found that family knowledge about the disease contributes to the perception of support and the use of strategies, in addition to these people, they have a high prevalence of symptoms of depression, anxiety and stress. It is concluded that social support and coping strategies of these patients play an important role in coping with HIV, especially when the family is aware of the disease and that it is important to address the mental health problems identified in the sample to contribute to improving the quality of life of these patients.