The phenomenon of digitalization together with the rise of technology are entities that have posed additional challenges for the regulation of intellectual property, especially in the labor context. Thus, this research focuses on the regulation of copyrights in labor contracts based on a comparative analysis between the Colombia and U.S. regimes, examining their characteristics, differences and/or similarities at the time of protecting the use of works. Therefore, a qualitative research was chosen, using a descriptive methodology for the legal analysis of the topic. As a result of the research, it was found that copyright in labor contexts presents challenges among the aforementioned regimes, reflecting different approaches to the protection of authors' rights. In addition, the lack of specific guarantees for authors underscores the need to ensure fair remuneration and adequate recognition of their rights in labor relations, another of the findings raised in this study.