Skin lesions are caused by prolonged pressure or friction between two hard planes leading perfusion block at this level and consequently ischemia that origins fast tissue degeneration. It constitutes a public health problem due to its repercussions in different areas such as the quality of life of patients and the consumption of resources for the health system. To determine the extrinsic factors related to the formation of skin lesions in patients hospitalized in a health care provider in Bucaramanga, during the period 2018B-2019B. A quantitative and longitudinal study was conducted in a cohort. This study included convenience sampling, monitoring for one week, a survey investigating sociodemographic data, extrinsic factors, skin condition. The Braden scale was used. Percentages and measures of central tendency were calculated. Statistical tests such as Pearson's chi-squared test, Fisher and the Mann–Whitney U test were applied to identify the difference between groups. 139 patients were surveyed from which 59.71% presented skin lesions. The extrinsic factors related to skin lesions were the humidity, pressure and friction using a p-value < 0.001. Shear was not statistically significant p=0.334. Being a woman and having incontinence are variables related to skin lesions. These findings agree with other national and international studies on skin lesions and its extrinsic factors. The humidity was the most predisposing extrinsic factor in the formation of skin lesions related to urinary incontinence of the patients.