This research analyzes the notion of knowledge transfer to business as a complex process that consists of identifying, acquiring and applying existing knowledge, through a process that requires a receiver and an issuer to bring about changes in the organizational behavior of a company. Company. This process of knowledge transfer is mainly carried out in three lines 1. knowledge transfer to small and medium enterprises, this line refers to the understanding of the organization, the transfer of intangible assets resulting from an evolutionary process that is of vital importance for the organizational development. 2. transfer of knowledge and social innovation, it is supported in generating responses to social phenomena or problems. From three models, the linear model, the dynamic model and the triple helix model. 3. transfer of scientific and technological knowledge in which the importance of the creation and innovation of spin-offs is highlighted. After constructing a conceptual referent, the creation of an instrument is made to assess the efficiency of the processes of the organizations, this instrument is based on the model of affirmation by evidence and is applied efficiently to some entrepreneurs.