Currently, worldwide the constant generation of Municipal Solid Waste (MSW) has become a challenge for humanity that requires different management models. The objective of this research is to carry out a thermodynamic and economic assessment that assesses the MSWs managed at the Bucaramanga (Carrasco) landfill, using Incineration technology for power generation (WtE). Ten scenarios were evaluated where regeneration, reheating and hybrid combined cycle (CCH) were incorporated. For the calculation of the properties in each state of the different scenarios, the CoolProp ™ software was used. The steam parameters of Rankine cycles were estimated at 40 bar and 380°C, with a lower heating value (LHV, MSW) of 8,786 kJ/kg. Highest energy efficiency was achieved on the scenario (C7) with 23.7%, increasing by 1.5 GWh/year (1.7%) power delivered to the grid with respect to the baseline scenario. The combined cycles hybrid of natural gas will increase the overall energy efficiency, around 37% to 39%, the mass flow rate of steam increases by 48% for the CCH1 and 66% for the CCH2, providing an increase in electrical power of 88% and 100.1%, respectively. Among the simple Rankine cycles, the scenario with a regenerator (C1) presents the best profitability, with a recovery period of 19 years, NPV of 6,878,103 USD and IRR of 11%. Of the hybrid combined cycles, the best profitability is the (CCH2), which returns the investment in the year 17, NPV of 31,754,531 USD and IRR of 13.7%, in this scenario the most important variable by income from plant is the sale of electricity, different from simple cycles, which are represented by the higher income by the MSW disposal rate.