Human genomics has revolutionized research on the molecular basis of human diseases and phenotypes (Hindorff et al., 2018). High throughput sequencing and genotyping platforms (Ke et al., 2016; LaFramboise, 2009) have facilitated the analysis of the variability and expression of the whole genome in a large number of studies for common and rare disorders (Buniello et al., 2019), such as Alzheimer's disease (Tosto and Reitz, 2016), cancer (Hansen and Bedard, 2013), heart diseases (Reuter et al., 2020), autoimmune
