An alternative approach to time delay estimation for the Bispectral Index (BIS) monitor is presented in this work. The practical implementation of the cross-correlation analysis (CCA) method is presented. The time delay estimation using windows and the robustness comparison between Peaks-Shift Correlation (PSC) and CCA methods are studied. Although both estimation methods are based on the correlation analysis, the time delay obtained with each one is different because the principle of the algorithms is different as