Objective: To conduct a systematic and multidimensional assessment of the relationship between interoception and fatigue in MS, integrating behavioral and neuroimaging evidence. Background: Fatigue is one of the most common and disabling symptoms in multiple sclerosis (MS). Although the pathophysiology of MS-related fatigue is poorly understood, abundant evidence points to a key role of altered interoceptive mechanism. Yet, no previous study has empirically evaluated the neurocognitive relationship between