Dyspnea in Patient with Collagen Disease, Infection?, Interstitial Lung Disease? why not Shrinking Lung Syndrome? Introduction: Systemic Lupus Erythematosus (SLE) is an inflammatory and multi-organ disease with prevalence between 12 to 36 cases per 100,000 people. During the course of the disease up to 50% of patients develop pulmonary compromise that can be pleuritis with or without effusion, fibrotic and inflammatory forms of lung disease, alveolar hemorrhage, Shrinking lung syndrome, pulmonary hypertension