INTRODUCTION: Pulmonary arterial hypertension (PAH) is a chronic disease, where the treatment to improve the functional class (FC) consists in combination of specific drugs. Although the cost of diagnosis and treatment are high, few studies exist around. This is important, especially in countries like Colombia where the budget to diagnose and treat high cost diseases are reduced. OBJECTIVE: To describe the direct and indirect costs of diagnose and treat PAH in Colombia following an appropriate diagnostic and treating