Multi-drug resistance in infection (MDR-TB) is defined as resistance to both rifampicin and isoniazid and it has Mycobacterium tuberculosis multiple complications and carries high risk for mortality, some of these complications like cavitated lesions, bronchiectasis and persistence of positive smears need surgical intervention for sterilization and for a appropriate evolution of the clinical case, we present the results of five patients who underwent surgery or were evaluated in our institution after their intervention. Methods: