Background: Systemic lupus erythematosus (SLE) is an immflamatory autoimmune systemic disorder that affects multiple organ systems and causes significant morbidity and mortality. Some of SLE patients require intensive care due to severe illnesses such as sepsis, cardiopulmonary, central nervous systems and renal involvement. The outcome factors in these patients are not well established. Objectives: To describe the causes of admission, course, and outcome of 15 patients admitted to a intensive care unit (ICU) in a referral