Background: We have recently observed a number of patients from Colombia with a distinctive endoscopic appearance characterized by multiple gastric hemorrhagic lesions occuring predominantly in the fundus, and in the absence of known predisposing conditions, such as physiological stress, portal hypertension, or chemical injury (eg, alcohol, NSAIDs). Objectives: To define the correlation between the endoscopic appearance and histopathological characteristics of the gastric mucosa in these patients and To explore its