The purpose of this paper is to detail a methodology for designing hybrid laboratories (HL) in manufacturing engineering. The proposed methodology includes physic and logic layers and also the HL management in its different modes of operation. The design takes into account the role of actors in learning science, technology, engineering and mathematics (STEM). Finally, a first learning experience involving students from the University of Castilla-La Mancha (UCLM) of Spain and EAN of Colombia will be detailed. Different pedagogical