INTRODUCTION In spite of the increasing survival rates in cystic fibrosis (CF) patients in the last few years, isolation of Candida species for diagnostic and therapeutic purposes still remains a challenge. We present the case of a patient with cystic fibrosis and Candida blankii isolation in bronchial secretions, resistant to treatment, progressive clinical deterioration and fatal outcome. CASE REPORT A 9 year-old patient with CF (genotype Phe508del/X) in multidisciplinary care at our institution, with previous isolations of Candida