Histoplasmosis is the most common systemic mycosis in the Center and South of America. Usually, infection is acquired via inhalation of H. spores, which are found in alkaline soils and areas contaminated with birds and bats excrement. Cleaning chicken pens, barns, capsulatum caves, constructions and soil manipulation have been described as a risk factor. Most of the times, infection is asymptomatic in immunocompetent patients unless they receive a high quantity of inoculum. Acute histoplasmosis is characterized by hematogenous