INTRODUCTION In Colombia, 10, 4% of the general population suffers from asthma. 7, 5% of these patients are adults and 10-30% require invasive mechanical ventilation (IMV) in the intensive care unit (ICU); with mortality rates of 1, 6/100.000 inhabitants. The use of extracorporeal membrane oxygenation (ECMO) has served as last resort when all other treatments have failed. The Extracorporeal Life Support Organization (ELSO) has documented very few cases of asthma managed with this therapy. We report a case of near