Introduction Dengue is an infectious disease with a high incidence in tropical and subtropical regions worldwide. It is caused by a virus named also as dengue, transmitted by vectors of the Aedes genus. This disease mainly courses with febrile stages, myalgia and articular pain, which is auto-resolved in the most of cases. However, 5 to 10% of the patients develop severity manifestations, characterized by vascular leakage, hemorrhages, organic dysfunction and in many cases, death. At the moment, the reasons whereby some patients