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C80-J THORACIC ONCOLOGY CASE REPORTS IV: Histologic Transformation From Non-Small Cell Lung Cancer (nsclc) Adenocarcinoma With EGFR-Mutant Exons 20 (s768i) And 21 (l858r) To Small Cell Lung Carcinoma (sclc): Case Report
Several biopsy samples with EGFR-mutant cancers patients have shown mechanisms to explain acquired resistance, including histological transformation from adenocarcinoma to Small Cell Lung Carcinoma (SCLC) which suggests a common cell-type origin for both malignancies. A probable explanation proposes that type-II alveolar cells, the origin cell of some EGFR-mutant adenocarcinomas, also have the potential to become SCLC.[...] on the basis of current evidence, we support standard SCLC therapy for SCLC combined with
Tópico:
Lung Cancer Research Studies
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Información de la Fuente:
FuenteAmerican Journal of Respiratory and Critical Care Medicine
