Discussion Histoplasmosis is a fungal infection caused by intracellular dimorphic fungus, it can be found in soil contaminated Histoplasma capsulatum by feces of animals such as bats and birds. Handling contaminated surfaces can make particles containing volatile microconidiae and thus enter through the airways by inhalation. Histoplasma have a particular tropism for macrophages. In most cases, the microorganism is trapped by the immune system cells controlling the infection. However, in cases of immunosuppression, this