The objective of the research was to determine the application of concept maps and problem-based learning in the development of cognitive skills in Health Education students of the Nursing Program at the Universidad Popular El Cesar, Colombia. The research was based on the quantitative approach, on a descriptive level with quasi-experimental design under the analytical empirical criterion. The study population consisted of 30 students, that is, two groups, A (experimental group) and B (control group), each with 15 students. The most