Hypophosphatasia (HPP) is a rare inherited disorder of bone and mineral metabolism. In this report, we describe the clinical manifestations and the molecular analysis of a Colombian patient with childhood HPP. In this patient, a homozygous c. 892G> A (p. E298K) mutation was detected in the ALPL gene. At 7 years of age, the right thoracic curve measured 30, which progressed to 40 by the age of 9 years. To our knowledge, only few cases of scoliosis have been reported in HPP. Given this association, we suggest to
