Options for uterine infertility that prevents parenthood are limited to gestational surrogacy or adoption. To demonstrate efficacy of the sheep as a model for uterine allograft transplantation and successful birth using assisted reproductive technology, advanced veterinary and neonatal care, non‐related African ewes (Sudanese and Ethiopian: n= 12) were studied. Each breed received the uterus from the other. Blood screening tests for parasitic/bacterial infection were used to assess tolerance to anesthesia (xylazine/ketamine