Quorum Sensing is a phenomenon of bacterial communication dependent on the density of the cell population, in which bacteria use signalling molecules to communicate and regulate the gene expression of different phenotypes at the group level. Some of the phenotypes regulated by this communication mechanism include bioluminescence, pigment production, motility and nitrogen fixation, among others. The QS signalling molecules most widely distributed in nature and, therefore, the most studied are the Acyl-Homoserine Lactones (AHLs), synthesized and detected by the proteins of the LuxI/LuxR families, respectively, which are present mostly in the Gram-negative bacteria. In a previous study by the research group Comunicación y Comunidades Bacterianas, bacterial isolates such as Stappia indica were obtained from corals, healthy and with Black Band disease, from the Colombian Caribbean. In the preliminary tests it was found that strains of this bacterium were involved in bacterial communication events regulated by QS (four of the diseased corals and one from a healthy coral). This phenomenon has not been reported in this bacterial species, therefore we proposed here its evaluation with experimental and computational approaches. Experimentally, by microbiological techniques and by chemical analysis AHL-like signal molecules, produced by different strains of S. indica, were detected, extracted and analysed qualitatively and, through a computational analysis, protein sequences of QS LuxI/LuxR-like systems were identified in this microorganism. This work represents the first report of the production of the Quorum Sensing signalling molecules such as Acyl-Homoserine lactones by Stappia indica, as well as the identification of their respective regulatory proteins.